Exploring the Structural Chemistry of Pyrophosphoramides: N,N′,N″,N‴-Tetraisopropylpyrophosphoramide

N,N′,N″,N‴-Tetraisopropylpyrophosphoramide 1 is a pyrophosphoramide with documented butyrylcholinesterase inhibition, property shared the more widely studied octamethylphosphoramide (Schradan). Unlike Schradan, solid at room temperature making it one of few known solids. The crystal structure was determined by single-crystal X-ray diffraction and compared that other previously described pyrophosphoramides. discussed in this study synthesised reacting iso-propyl amine pyrophosphoryl tetrachloride under anhydrous conditions. A unique supramolecular motif observed when published structures having two different intermolecular hydrogen bonding synthons. Furthermore, potential wider variety which similar pyrophosphoramides can crystallise recognised. Proton (1H) Phosphorus 31 (31P) Nuclear Magnetic Resonance (NMR) spectroscopy, infrared (IR) mass spectrometry (MS) were carried out to complete analysis compound.